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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study, including the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be reliable and reduce bias in results is also essential. Too much heterogeneity, however could cause issues with the trial design.

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The goal of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They also provide a useful method to determine the cause-effect relationship between an intervention and its results. However, they shouldn’t be used in lieu for explanatory studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform policy and practice decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, 프라그마틱 슬롯 사이트 슈가러쉬, Bookmarkpagerank.com, including recruitment, design and delivery of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.